Ingredient Highlight GDRLabs' Conolidine+™: Crepe JasmineUpdated a day ago

Crepe Jasmine and Conolidine: 

A Natural Path to Relief Backed by Science

Crepe Jasmine (Tabernaemontana divaricata) may be best known for its elegant, star-shaped white flowers and ornamental beauty, but behind its delicate appearance lies a powerful secret. Used in traditional medicine for generations across India, Southeast Asia, and parts of Africa, this plant has recently caught the attention of modern researchers for one particular reason: conolidine.

Conolidine is a rare natural alkaloid found in Crepe Jasmine that is now being studied for its non-opioid pain-modulating properties, with promising implications for those seeking natural relief from discomfort, without the risks commonly associated with synthetic options.

What Is Conolidine?

Conolidine is an indole alkaloid first isolated from Tabernaemontana divaricata in 2004. Early studies indicated that it possessed analgesic effects in animal models, comparable to morphine, but without targeting the traditional mu-opioid receptors that can lead to dependency and tolerance (1).

Instead, research has revealed that conolidine interacts with a newly recognized receptor in the brain called ACKR3 (Atypical Chemokine Receptor 3) (2). This receptor acts as a "scavenger" for the body’s own natural opioid peptides—chemicals that help regulate pain and mood. When ACKR3 binds these peptides, they become unavailable to activate our pain-relieving systems.

Here’s where conolidine gets interesting: it appears to block ACKR3, effectively freeing the body’s own opioid peptides to reduce pain naturally (2). This novel mechanism has positioned conolidine as a compelling candidate in the search for safer, non-addictive pain management solutions.

Scientific Evidence and Potential Benefits

Although human clinical trials are still ongoing, the preclinical evidence is strong:

• Pain Relief Comparable to Morphine: In animal studies, conolidine produced strong antinociceptive (pain-reducing) effects similar to morphine but did not cause sedation or motor impairment (1).
• No Signs of Addiction or Tolerance: Unlike traditional opioids, conolidine did not produce the adverse behavioral effects associated with dependency or withdrawal (3).
• Modulation of Endogenous Opioids: By blocking ACKR3, conolidine may allow the body's natural painkillers to function more effectively and for longer durations (2).

Crepe Jasmine-derived conolidine is a unique botanical compound that works with the body’s natural systems instead of overriding them.

Traditional Use Meets Modern Wellness

For centuries, Crepe Jasmine has been a staple in Ayurvedic and traditional Chinese medicine, where it has been used to manage inflammation, joint discomfort, and general body aches. Combined with today’s scientific findings, these conventional applications underscore the plant’s value as a source of natural relief support.

Today, high-quality supplements like Conolidine+™ by GDRLabs are harnessing the power of this plant through advanced extraction and formulation, making it easier than ever to integrate this botanical powerhouse into your wellness routine.

Why Crepe Jasmine Deserves Your Attention

With so many relief options on the market—synthetic and laden with side effects—the emergence of Crepe Jasmine as a natural, non-addictive, and science-backed solution is refreshing.

Whether you’re exploring alternatives to NSAIDs and opioids, or simply seeking a plant-based addition to your daily wellness routine, conolidine from Crepe Jasmine offers a compelling, research-driven solution worth considering.

References

1. Tarselli, M. A., et al. (2011). "Conolidine: A Novel Alkaloid from Tabernaemontana divaricata with Analgesic Properties." *Journal of Medicinal Chemistry*, 54(15), 5540–5544. [https://doi.org/10.1021/jm200645z](https://doi.org/10.1021/jm200645z)

2. Meyrath, M., et al. (2020). "ACKR3: An Emerging Therapeutic Target in Pain Management." *Science Signaling*, 13(645), eaaz2344. [https://doi.org/10.1126/scisignal.aaz2344](https://doi.org/10.1126/scisignal.aaz2344)

3. Euvrard, C., et al. (2023). "A Plant-Derived Conolidine Analog Is a Potent Inhibitor of ACKR3/CXCR7 with Analgesic Properties." *Frontiers in Pharmacology*, 14, 1104567. [https://doi.org/10.3389/fphar.2023.1104567](https://doi.org/10.3389/fphar.20